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ProteoDisco

This is the released version of ProteoDisco; for the devel version, see ProteoDisco.

Generation of customized protein variant databases from genomic variants, splice-junctions and manual sequences


Bioconductor version: Release (3.23)

ProteoDisco is an R package to facilitate proteogenomics studies. It houses functions to create customized (variant) protein databases based on user-submitted genomic variants, splice-junctions, fusion genes and manual transcript sequences. The flexible workflow can be adopted to suit a myriad of research and experimental settings.

Author: Job van Riet [cre], Wesley van de Geer [aut], Harmen van de Werken [ths]

Maintainer: Job van Riet <jobvriet at gmail.com>

Citation (from within R, enter citation("ProteoDisco")):
Seminal Bioconductor project articles:

Huber W, Carey VJ, Gentleman R, Anders S, Carlson M, Carvalho BS, Bravo HC, Davis S, Gatto L, Girke T, Gottardo R, Hahne F, Hansen KD, Irizarry RA, Lawrence M, Love MI, MacDonald J, Obenchain V, Oleś AK, Pagès H, Reyes A, Shannon P, Smyth GK, Tenenbaum D, Waldron L, Morgan M (2015). "Orchestrating high-throughput genomic analysis with Bioconductor." Nature Methods, 12(2), 115–121. doi:10.1038/nmeth.3252.

Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JYH, Zhang J (2004). "Bioconductor: open software development for computational biology and bioinformatics." Genome Biology, 5(10), R80. doi:10.1186/gb-2004-5-10-r80.

Installation

To install this package, start R (version "4.6") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("ProteoDisco")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("ProteoDisco")
Overview_Proteodisco HTML R Script
Reference Manual PDF
NEWS Text

Details

biocViews DataImport, Proteomics, RNASeq, SNP, Sequencing, Software, VariantAnnotation
Version 1.18.0
In Bioconductor since BioC 3.14 (R-4.1) (5 years)
License GPL-3
Depends R (>= 4.1.0)
Imports BiocGenerics(>= 0.38.0), BiocParallel(>= 1.26.0), Biostrings(>= 2.60.1), checkmate (>= 2.0.0), cleaver(>= 1.30.0), dplyr (>= 1.0.6), GenomeInfoDb(>= 1.28.0), GenomicFeatures(>= 1.44.0), GenomicRanges(>= 1.44.0), IRanges(>= 2.26.0), methods (>= 4.1.0), ParallelLogger (>= 2.0.1), plyr (>= 1.8.6), rlang (>= 0.4.11), S4Vectors(>= 0.30.0), Seqinfo, tibble (>= 3.1.2), tidyr (>= 1.1.3), VariantAnnotation(>= 1.36.0), XVector(>= 0.32.0)
System Requirements
URL https://github.com/ErasmusMC-CCBC/ProteoDisco
Bug Reports https://github.com/ErasmusMC-CCBC/ProteoDisco/issues
See More
Suggests AnnotationDbi(>= 1.54.1), BSgenome(>= 1.60.0), BSgenome.Hsapiens.UCSC.hg19(>= 1.4.3), BiocStyle(>= 2.20.1), DelayedArray(>= 0.18.0), devtools (>= 2.4.2), knitr (>= 1.33), matrixStats (>= 0.59.0), markdown (>= 1.1), org.Hs.eg.db(>= 3.13.0), purrr (>= 0.3.4), RCurl (>= 1.98.1.3), readr (>= 1.4.0), ggplot2 (>= 3.3.5), rmarkdown (>= 2.9), rtracklayer(>= 1.52.0), seqinr (>= 4.2.8), stringr (>= 1.4.0), reshape2 (>= 1.4.4), scales (>= 1.1.1), testthat (>= 3.0.3), TxDb.Hsapiens.UCSC.hg19.knownGene(>= 3.2.2)
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package ProteoDisco_1.18.0.tar.gz
Windows Binary (x86_64) ProteoDisco_1.18.0.zip
macOS Binary (big-sur-x86_64) ProteoDisco_1.18.0.tgz
macOS Binary (sonoma-arm64) ProteoDisco_1.18.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/ProteoDisco
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/ProteoDisco
Bioc Package Browser https://code.bioconductor.org/browse/ProteoDisco/
Package Short Url https://bioconductor.org/packages/ProteoDisco/
Package Downloads Report Download Stats