Package: crisprScore
Version: 1.15.3
Date: 2026-04-02
Title: On-Target and Off-Target Scoring Algorithms for CRISPR gRNAs
Authors@R: c(
    person("Jean-Philippe", "Fortin", email = "fortin946@gmail.com", role = c("aut", "cre", "cph")),
    person("Aaron", "Lun", email = "infinite.monkeys.with.keyboards@gmail.com", role = c("aut")),
    person("Luke", "Hoberecht", email = "lukehob3@gmail.com", role = c("ctb")),
    person("Pirunthan", "Perampalam", email = "pirunthan@gmail.com", role = c("ctb")))
Depends: R (>= 4.1), crisprScoreData (>= 1.1.3)
Imports: BiocGenerics, Biostrings, IRanges, methods, randomForest,
        reticulate, stringr, utils, XVector
Suggests: BiocStyle, knitr, rmarkdown, testthat
biocViews: CRISPR, FunctionalGenomics, FunctionalPrediction
Description: Provides R wrappers of several on-target and off-target
        scoring methods for CRISPR guide RNAs (gRNAs). The following
        nucleases are supported: SpCas9, AsCas12a, enAsCas12a, and
        RfxCas13d (CasRx). The available on-target cutting efficiency
        scoring methods are RuleSet1, RuleSet3, DeepHF, enPAM+GB, and
        CRISPRscan. Both the CFD and MIT scoring methods are available
        for off-target specificity prediction. The package also
        provides a Lindel-derived score to predict the probability of a
        gRNA to produce indels inducing a frameshift for the Cas9
        nuclease. Note that DeepHF and enPAM+GB are not available on
        Windows machines.
License: MIT + file LICENSE
Encoding: UTF-8
RoxygenNote: 7.3.3
VignetteBuilder: knitr
StagedInstall: no
BugReports: https://github.com/crisprVerse/crisprScore
URL: https://github.com/crisprVerse/crisprScore/issues
LazyData: true
Config/pak/sysreqs: libicu-dev libpng-dev libssl-dev python3 zlib1g-dev
Repository: https://bioc.r-universe.dev
Date/Publication: 2026-04-02 15:45:33 UTC
RemoteUrl: https://github.com/bioc/crisprScore
RemoteRef: HEAD
RemoteSha: cbd6f9f60dc7fb50d14b90485b9561d582caf21e
NeedsCompilation: no
Packaged: 2026-04-03 04:34:20 UTC; root
Author: Jean-Philippe Fortin [aut, cre, cph],
  Aaron Lun [aut],
  Luke Hoberecht [ctb],
  Pirunthan Perampalam [ctb]
Maintainer: Jean-Philippe Fortin <fortin946@gmail.com>
Built: R 4.6.0; ; 2026-04-03 04:40:38 UTC; windows
