Package: SplineDV
Type: Package
Title: Differential Variability (DV) analysis for single-cell RNA
        sequencing data. (e.g. Identify Differentially Variable Genes
        across two experimental conditions)
Description: A spline based scRNA-seq method for identifying
        differentially variable (DV) genes across two experimental
        conditions. Spline-DV constructs a 3D spline from 3 key gene
        statistics: mean expression, coefficient of variance, and
        dropout rate. This is done for both conditions. The 3D spline
        provides the “expected” behavior of genes in each condition.
        The distance of the observed mean, CV and dropout rate of each
        gene from the expected 3D spline is used to measure
        variability. As the final step, the spline-DV method compares
        the variabilities of each condition to identify differentially
        variable (DV) genes.
Version: 1.3.0
Authors@R: c(
    person(given = "Shreyan", family = "Gupta", email = "xenon8778@tamu.edu", role = c("aut", "cre"), comment = c(ORCID = '0000-0002-1904-9862')),
    person(given = "James", family = "Cai", role = "aut", comment = c(ORCID = '0000-0002-8081-6725')))
BugReports: https://github.com/Xenon8778/SplineDV/issues
URL: https://github.com/Xenon8778/SplineDV
License: GPL-2
Encoding: UTF-8
biocViews: Software, SingleCell, Sequencing, DifferentialExpression,
        RNASeq, GeneExpression, Transcriptomics, FeatureExtraction
Depends: R (>= 3.5.0)
Imports: plotly, dplyr, scuttle, methods, Biobase, BiocGenerics,
        S4Vectors, sparseMatrixStats, SingleCellExperiment,
        SummarizedExperiment, Matrix (>= 1.6.4), utils
Suggests: knitr, DelayedMatrixStats, rmarkdown, BiocStyle, ggplot2,
        ggpubr, MASS, scales, scRNAseq, testthat (>= 3.0.0)
VignetteBuilder: knitr
RoxygenNote: 7.3.2
Config/testthat/edition: 3
Config/pak/sysreqs: make libicu-dev libssl-dev zlib1g-dev
Repository: https://bioc.r-universe.dev
Date/Publication: 2025-10-29 15:33:07 UTC
RemoteUrl: https://github.com/bioc/SplineDV
RemoteRef: HEAD
RemoteSha: 0bab677500547d7f2e49f576a4b76fd57def1166
NeedsCompilation: no
Packaged: 2026-03-03 08:16:32 UTC; root
Author: Shreyan Gupta [aut, cre] (ORCID:
    <https://orcid.org/0000-0002-1904-9862>),
  James Cai [aut] (ORCID: <https://orcid.org/0000-0002-8081-6725>)
Maintainer: Shreyan Gupta <xenon8778@tamu.edu>
Built: R 4.6.0; ; 2026-03-03 08:19:17 UTC; windows
