Package: DifferentialRegulation
Type: Package
Title: Differentially regulated genes from scRNA-seq data
Version: 2.7.0
Description: DifferentialRegulation is a method for detecting differentially regulated genes between 
  two groups of samples (e.g., healthy vs. disease, or treated vs. untreated samples),
  by targeting differences in the balance of spliced and unspliced mRNA abundances, 
  obtained from single-cell RNA-sequencing (scRNA-seq) data.
  From a mathematical point of view, DifferentialRegulation accounts for the sample-to-sample variability, 
  and embeds multiple samples in a Bayesian hierarchical model.
  Furthermore, our method also deals with two major sources of mapping uncertainty:
  i) 'ambiguous' reads, compatible with both spliced and unspliced versions of a gene,
  and ii) reads mapping to multiple genes.
  In particular, ambiguous reads are treated separately from spliced and unsplced reads, 
  while reads that are compatible with multiple genes are allocated to the gene of origin.
  Parameters are inferred via Markov chain Monte Carlo (MCMC) techniques (Metropolis-within-Gibbs).
Authors@R: c(person(given = "Simone",
           family = "Tiberi",
           role = c("aut", "cre"),
           email = "simone.tiberi@unibo.it",
           comment = c(ORCID = "0000-0002-3054-9964")),
           person(given = "Charlotte", family = "Soneson", 
           role = c("aut"),
           email = "charlottesoneson@gmail.com",
           comment = c(ORCID = "0000-0003-3833-2169")))
biocViews: DifferentialSplicing, Bayesian, Genetics, RNASeq,
        Sequencing, DifferentialExpression, GeneExpression,
        MultipleComparison, Software, Transcription, StatisticalMethod,
        Visualization, SingleCell, GeneTarget
License: GPL-3
Depends: R (>= 4.3.0)
Imports: methods, Rcpp, doRNG, MASS, data.table, doParallel, parallel,
        foreach, stats, BANDITS, Matrix, SingleCellExperiment,
        SummarizedExperiment, ggplot2, tximport, gridExtra
LinkingTo: Rcpp, RcppArmadillo
Suggests: knitr, rmarkdown, testthat, BiocStyle
SystemRequirements: C++17
VignetteBuilder: knitr
RoxygenNote: 7.3.2
ByteCompile: true
Encoding: UTF-8
URL: https://github.com/SimoneTiberi/DifferentialRegulation
BugReports: https://github.com/SimoneTiberi/DifferentialRegulation/issues
git_url: https://git.bioconductor.org/packages/DifferentialRegulation
git_branch: devel
git_last_commit: ab313f3
git_last_commit_date: 2025-04-15
Repository: Bioconductor 3.22
Date/Publication: 2025-06-04
NeedsCompilation: yes
Packaged: 2025-06-04 22:40:26 UTC; biocbuild
Author: Simone Tiberi [aut, cre] (ORCID:
    <https://orcid.org/0000-0002-3054-9964>),
  Charlotte Soneson [aut] (ORCID:
    <https://orcid.org/0000-0003-3833-2169>)
Maintainer: Simone Tiberi <simone.tiberi@unibo.it>
Built: R 4.5.0; x86_64-w64-mingw32; 2025-06-05 12:51:39 UTC; windows
Archs: x64
