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pairedGSEA

This is the development version of pairedGSEA; for the stable release version, see pairedGSEA.

Paired DGE and DGS analysis for gene set enrichment analysis


Bioconductor version: Development (3.24)

pairedGSEA makes it simple to run a paired Differential Gene Expression (DGE) and Differencital Gene Splicing (DGS) analysis. The package allows you to store intermediate results for further investiation, if desired. pairedGSEA comes with a wrapper function for running an Over-Representation Analysis (ORA) and functionalities for plotting the results.

Author: Søren Helweg Dam [cre, aut] ORCID iD ORCID: 0000-0002-9895-0930 , Lars Rønn Olsen [aut] ORCID iD ORCID: 0000-0002-6725-7850 , Kristoffer Vitting-Seerup [aut] ORCID iD ORCID: 0000-0002-6450-0608

Maintainer: Søren Helweg Dam <sohdam at dtu.dk>

Citation (from within R, enter citation("pairedGSEA")):
Seminal Bioconductor project articles:

Huber W, Carey VJ, Gentleman R, Anders S, Carlson M, Carvalho BS, Bravo HC, Davis S, Gatto L, Girke T, Gottardo R, Hahne F, Hansen KD, Irizarry RA, Lawrence M, Love MI, MacDonald J, Obenchain V, Oleś AK, Pagès H, Reyes A, Shannon P, Smyth GK, Tenenbaum D, Waldron L, Morgan M (2015). "Orchestrating high-throughput genomic analysis with Bioconductor." Nature Methods, 12(2), 115–121. doi:10.1038/nmeth.3252.

Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JYH, Zhang J (2004). "Bioconductor: open software development for computational biology and bioinformatics." Genome Biology, 5(10), R80. doi:10.1186/gb-2004-5-10-r80.

Installation

To install this package, start R (version "4.6") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

## The following initializes the development version of Bioconductor
BiocManager::install(version = "devel")

BiocManager::install("pairedGSEA")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("pairedGSEA")
User Guide HTML R Script
Reference Manual PDF
NEWS Text
LICENSE Text

Details

biocViews AlternativeSplicing, DifferentialExpression, DifferentialSplicing, GeneExpression, GeneSetEnrichment, ImmunoOncology, Pathways, RNASeq, Software, Transcription
Version 1.13.0
In Bioconductor since BioC 3.17 (R-4.3) (3.5 years)
License MIT + file LICENSE
Depends R (>= 4.4.0)
Imports DESeq2, DEXSeq, limma, fgsea, msigdbr, sva, SummarizedExperiment, S4Vectors, BiocParallel, ggplot2, aggregation, stats, utils, methods, showtext
System Requirements
URL https://github.com/shdam/pairedGSEA
Bug Reports https://github.com/shdam/pairedGSEA/issues
See More
Suggests writexl, readxl, readr, rhdf5, plotly, testthat (>= 3.0.0), knitr, rmarkdown, BiocStyle, covr
Linking To
Enhances
Depends On Me
Imports Me
Suggests Me
Links To Me
Build Report Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package pairedGSEA_1.13.0.tar.gz
Windows Binary (x86_64) pairedGSEA_1.13.0.zip (64-bit only)
macOS Binary (big-sur-x86_64) pairedGSEA_1.13.0.tgz
macOS Binary (sonoma-arm64) pairedGSEA_1.13.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/pairedGSEA
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/pairedGSEA
Bioc Package Browser https://code.bioconductor.org/browse/pairedGSEA/
Package Short Url https://bioconductor.org/packages/pairedGSEA/
Package Downloads Report Download Stats