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multiGSEA

This is the development version of multiGSEA; for the stable release version, see multiGSEA.

Combining GSEA-based pathway enrichment with multi omics data integration


Bioconductor version: Development (3.24)

Extracted features from pathways derived from 8 different databases (KEGG, Reactome, Biocarta, etc.) can be used on transcriptomic, proteomic, and/or metabolomic level to calculate a combined GSEA-based enrichment score.

Author: Sebastian Canzler [aut, cre] ORCID iD ORCID: 0000-0001-7935-9582 , Jörg Hackermüller [aut] ORCID iD ORCID: 0000-0003-4920-7072

Maintainer: Sebastian Canzler <sebastian.canzler at ufz.de>

Citation (from within R, enter citation("multiGSEA")):
Seminal Bioconductor project articles:

Huber W, Carey VJ, Gentleman R, Anders S, Carlson M, Carvalho BS, Bravo HC, Davis S, Gatto L, Girke T, Gottardo R, Hahne F, Hansen KD, Irizarry RA, Lawrence M, Love MI, MacDonald J, Obenchain V, Oleś AK, Pagès H, Reyes A, Shannon P, Smyth GK, Tenenbaum D, Waldron L, Morgan M (2015). "Orchestrating high-throughput genomic analysis with Bioconductor." Nature Methods, 12(2), 115–121. doi:10.1038/nmeth.3252.

Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JYH, Zhang J (2004). "Bioconductor: open software development for computational biology and bioinformatics." Genome Biology, 5(10), R80. doi:10.1186/gb-2004-5-10-r80.

Installation

To install this package, start R (version "4.6") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

## The following initializes the development version of Bioconductor
BiocManager::install(version = "devel")

BiocManager::install("multiGSEA")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("multiGSEA")
multiGSEA.html HTML R Script
Reference Manual PDF
NEWS Text

Details

biocViews BioCarta, GeneSetEnrichment, Pathways, Reactome, Software
Version 1.23.0
In Bioconductor since BioC 3.12 (R-4.0) (6 years)
License GPL-3
Depends R (>= 4.0.0)
Imports magrittr, graphite, AnnotationDbi, metaboliteIDmapping, dplyr, fgsea, metap, rappdirs, rlang, methods
System Requirements
URL https://github.com/yigbt/multiGSEA
Bug Reports https://github.com/yigbt/multiGSEA/issues
See More
Suggests org.Hs.eg.db, org.Mm.eg.db, org.Rn.eg.db, org.Ss.eg.db, org.Bt.eg.db, org.Ce.eg.db, org.Dm.eg.db, org.Dr.eg.db, org.Gg.eg.db, org.Xl.eg.db, org.Cf.eg.db, knitr, rmarkdown, BiocStyle, testthat (>= 2.1.0)
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package multiGSEA_1.23.0.tar.gz
Windows Binary (x86_64) multiGSEA_1.23.0.zip
macOS Binary (big-sur-x86_64) multiGSEA_1.23.0.tgz
macOS Binary (sonoma-arm64) multiGSEA_1.23.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/multiGSEA
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/multiGSEA
Bioc Package Browser https://code.bioconductor.org/browse/multiGSEA/
Package Short Url https://bioconductor.org/packages/multiGSEA/
Package Downloads Report Download Stats