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gemma.R

This is the development version of gemma.R; for the stable release version, see gemma.R.

A wrapper for Gemma's Restful API to access curated gene expression data and differential expression analyses


Bioconductor version: Development (3.24)

Low- and high-level wrappers for Gemma's RESTful API. They enable access to curated expression and differential expression data from over 10,000 published studies. Gemma is a web site, database and a set of tools for the meta-analysis, re-use and sharing of genomics data, currently primarily targeted at the analysis of gene expression profiles.

Author: Javier Castillo-Arnemann [aut] ORCID iD ORCID: 0000-0002-5626-9004 , Jordan Sicherman [aut] ORCID iD ORCID: 0000-0001-8160-4567 , Ogan Mancarci [aut] ORCID iD ORCID: 0000-0002-1452-0889 , Guillaume Poirier-Morency [aut] ORCID iD ORCID: 0000-0002-6554-0441 , Paul Pavlidis [aut, cre] ORCID iD ORCID: 0000-0002-0426-5028

Maintainer: Paul Pavlidis <paul at msl.ubc.ca>

Citation (from within R, enter citation("gemma.R")):
Seminal Bioconductor project articles:

Huber W, Carey VJ, Gentleman R, Anders S, Carlson M, Carvalho BS, Bravo HC, Davis S, Gatto L, Girke T, Gottardo R, Hahne F, Hansen KD, Irizarry RA, Lawrence M, Love MI, MacDonald J, Obenchain V, Oleś AK, Pagès H, Reyes A, Shannon P, Smyth GK, Tenenbaum D, Waldron L, Morgan M (2015). "Orchestrating high-throughput genomic analysis with Bioconductor." Nature Methods, 12(2), 115–121. doi:10.1038/nmeth.3252.

Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JYH, Zhang J (2004). "Bioconductor: open software development for computational biology and bioinformatics." Genome Biology, 5(10), R80. doi:10.1186/gb-2004-5-10-r80.

Installation

To install this package, start R (version "4.6") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

## The following initializes the development version of Bioconductor
BiocManager::install(version = "devel")

BiocManager::install("gemma.R")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("gemma.R")
A guide to metadata for samples and differential expression analyses HTML R Script
A meta analysis on effects of Parkinson's Disease using Gemma.R HTML R Script
Accessing curated gene expression data with gemma.R HTML R Script
Reference Manual PDF
NEWS Text

Details

biocViews Annotation, BatchEffect, Bayesian, DataImport, DifferentialExpression, ExperimentalDesign, GeneExpression, Microarray, Normalization, Preprocessing, SingleCell, Software, ThirdPartyClient
Version 3.9.1
In Bioconductor since BioC 3.16 (R-4.2) (4 years)
License Apache License (>= 2)
Depends R (>= 4.1.0)
Imports magrittr, glue, memoise, jsonlite, data.table, rlang, lubridate, utils, stringr, SummarizedExperiment, Biobase, tibble, tidyr, S4Vectors, httr, rappdirs, bit64, assertthat, digest, R.utils, kableExtra, base64enc, pheatmap
System Requirements
URL https://pavlidislab.github.io/gemma.R/ https://github.com/PavlidisLab/gemma.R
Bug Reports https://github.com/PavlidisLab/gemma.R/issues
See More
Suggests testthat (>= 2.0.0), rmarkdown, knitr, dplyr, covr, ggplot2, ggrepel, BiocStyle, microbenchmark, magick, purrr, viridis, poolr, listviewer, shiny
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package gemma.R_3.9.1.tar.gz
Windows Binary (x86_64) gemma.R_3.9.1.zip
macOS Binary (big-sur-x86_64) gemma.R_3.9.1.tgz
macOS Binary (sonoma-arm64) gemma.R_3.9.1.tgz
Source Repository git clone https://git.bioconductor.org/packages/gemma.R
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/gemma.R
Bioc Package Browser https://code.bioconductor.org/browse/gemma.R/
Package Short Url https://bioconductor.org/packages/gemma.R/
Package Downloads Report Download Stats