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PhenoGeneRanker

This is the development version of PhenoGeneRanker; for the stable release version, see PhenoGeneRanker.

PhenoGeneRanker: A gene and phenotype prioritization tool


Bioconductor version: Development (3.24)

This package is a gene/phenotype prioritization tool that utilizes multiplex heterogeneous gene phenotype network. PhenoGeneRanker allows multi-layer gene and phenotype networks. It also calculates empirical p-values of gene/phenotype ranking using random stratified sampling of genes/phenotypes based on their connectivity degree in the network. https://dl.acm.org/doi/10.1145/3307339.3342155.

Author: Cagatay Dursun [aut, cre]

Maintainer: Cagatay Dursun <cagataydursun at gmail.com>

Citation (from within R, enter citation("PhenoGeneRanker")):
Seminal Bioconductor project articles:

Huber W, Carey VJ, Gentleman R, Anders S, Carlson M, Carvalho BS, Bravo HC, Davis S, Gatto L, Girke T, Gottardo R, Hahne F, Hansen KD, Irizarry RA, Lawrence M, Love MI, MacDonald J, Obenchain V, Oleś AK, Pagès H, Reyes A, Shannon P, Smyth GK, Tenenbaum D, Waldron L, Morgan M (2015). "Orchestrating high-throughput genomic analysis with Bioconductor." Nature Methods, 12(2), 115–121. doi:10.1038/nmeth.3252.

Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JYH, Zhang J (2004). "Bioconductor: open software development for computational biology and bioinformatics." Genome Biology, 5(10), R80. doi:10.1186/gb-2004-5-10-r80.

Installation

To install this package, start R (version "4.6") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

## The following initializes the development version of Bioconductor
BiocManager::install(version = "devel")

BiocManager::install("PhenoGeneRanker")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("PhenoGeneRanker")
PhenoGeneRanker HTML R Script
Reference Manual PDF
NEWS Text

Details

biocViews BiomedicalInformatics, GenePrediction, GraphAndNetwork, Network, NetworkInference, Pathways, Software, SystemsBiology
Version 1.21.0
In Bioconductor since BioC 3.13 (R-4.1) (5 years)
License Creative Commons Attribution 4.0 International License
Depends
Imports igraph, Matrix, foreach, doParallel, dplyr, stats, utils, parallel
System Requirements
URL
See More
Suggests knitr, rmarkdown
Linking To
Enhances
Depends On Me
Imports Me
Suggests Me
Links To Me
Build Report Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package PhenoGeneRanker_1.21.0.tar.gz
Windows Binary (x86_64) PhenoGeneRanker_1.21.0.zip
macOS Binary (big-sur-x86_64) PhenoGeneRanker_1.21.0.tgz
macOS Binary (sonoma-arm64) PhenoGeneRanker_1.21.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/PhenoGeneRanker
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/PhenoGeneRanker
Bioc Package Browser https://code.bioconductor.org/browse/PhenoGeneRanker/
Package Short Url https://bioconductor.org/packages/PhenoGeneRanker/
Package Downloads Report Download Stats