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MSstats

This is the development version of MSstats; for the stable release version, see MSstats.

Protein Significance Analysis in DDA, SRM and DIA for Label-free or Label-based Proteomics Experiments


Bioconductor version: Development (3.24)

A set of tools for statistical relative protein significance analysis in DDA, SRM and DIA experiments.

Author: Meena Choi [aut, cre], Mateusz Staniak [aut], Devon Kohler [aut], Tony Wu [aut], Deril Raju [aut], Tsung-Heng Tsai [aut], Ting Huang [aut], Olga Vitek [aut]

Maintainer: Meena Choi <mnchoi67 at gmail.com>

Citation (from within R, enter citation("MSstats")):
Seminal Bioconductor project articles:

Huber W, Carey VJ, Gentleman R, Anders S, Carlson M, Carvalho BS, Bravo HC, Davis S, Gatto L, Girke T, Gottardo R, Hahne F, Hansen KD, Irizarry RA, Lawrence M, Love MI, MacDonald J, Obenchain V, Oleś AK, Pagès H, Reyes A, Shannon P, Smyth GK, Tenenbaum D, Waldron L, Morgan M (2015). "Orchestrating high-throughput genomic analysis with Bioconductor." Nature Methods, 12(2), 115–121. doi:10.1038/nmeth.3252.

Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JYH, Zhang J (2004). "Bioconductor: open software development for computational biology and bioinformatics." Genome Biology, 5(10), R80. doi:10.1186/gb-2004-5-10-r80.

Installation

To install this package, start R (version "4.6") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

## The following initializes the development version of Bioconductor
BiocManager::install(version = "devel")

BiocManager::install("MSstats")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("MSstats")
MSstats+: Peak quality-weighted differential analysis HTML R Script
MSstats: End to End Workflow HTML R Script
MSstats: Metabolomics workflow with MZMine HTML R Script
MSstats: Protein/Peptide significance analysis HTML R Script
Reference Manual PDF
LICENSE Text

Details

biocViews ImmunoOncology, MassSpectrometry, Normalization, Proteomics, QualityControl, Software, TimeCourse
Version 4.21.1
In Bioconductor since BioC 2.13 (R-3.0) (13 years)
License Artistic-2.0
Depends R (>= 4.0)
Imports MSstatsConvert, data.table, checkmate, MASS, htmltools, limma, lme4, preprocessCore, survival, utils, Rcpp, ggplot2 (>= 3.4.0), ggrepel, gplots, plotly, marray, stats, grDevices, graphics, methods, statmod, parallel, rlang
System Requirements
URL http://msstats.org
Bug Reports https://groups.google.com/forum/#!forum/msstats
See More
Suggests BiocStyle, knitr, rmarkdown, tinytest, covr, markdown, mockery, kableExtra
Linking To Rcpp, RcppArmadillo
Enhances
Depends On Me MSstatsBioNet
Imports Me artMS, MSstatsBig, MSstatsLiP, MSstatsPTM, MSstatsTMT
Suggests Me MSstatsResponse
Links To Me
Build Report Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package MSstats_4.21.1.tar.gz
Windows Binary (x86_64) MSstats_4.21.0.zip
macOS Binary (big-sur-x86_64) MSstats_4.21.1.tgz
macOS Binary (sonoma-arm64) MSstats_4.21.1.tgz
Source Repository git clone https://git.bioconductor.org/packages/MSstats
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/MSstats
Bioc Package Browser https://code.bioconductor.org/browse/MSstats/
Package Short Url https://bioconductor.org/packages/MSstats/
Package Downloads Report Download Stats