Bioc2026 Registration Open!

HGC

This is the development version of HGC; for the stable release version, see HGC.

A fast hierarchical graph-based clustering method


Bioconductor version: Development (3.24)

HGC (short for Hierarchical Graph-based Clustering) is an R package for conducting hierarchical clustering on large-scale single-cell RNA-seq (scRNA-seq) data. The key idea is to construct a dendrogram of cells on their shared nearest neighbor (SNN) graph. HGC provides functions for building graphs and for conducting hierarchical clustering on the graph. The users with old R version could visit https://github.com/XuegongLab/HGC/tree/HGC4oldRVersion to get HGC package built for R 3.6.

Author: Zou Ziheng [aut], Hua Kui [aut], XGlab [cre, cph]

Maintainer: XGlab <xglab at mail.tsinghua.edu.cn>

Citation (from within R, enter citation("HGC")):
Seminal Bioconductor project articles:

Huber W, Carey VJ, Gentleman R, Anders S, Carlson M, Carvalho BS, Bravo HC, Davis S, Gatto L, Girke T, Gottardo R, Hahne F, Hansen KD, Irizarry RA, Lawrence M, Love MI, MacDonald J, Obenchain V, Oleś AK, Pagès H, Reyes A, Shannon P, Smyth GK, Tenenbaum D, Waldron L, Morgan M (2015). "Orchestrating high-throughput genomic analysis with Bioconductor." Nature Methods, 12(2), 115–121. doi:10.1038/nmeth.3252.

Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JYH, Zhang J (2004). "Bioconductor: open software development for computational biology and bioinformatics." Genome Biology, 5(10), R80. doi:10.1186/gb-2004-5-10-r80.

Installation

To install this package, start R (version "4.6") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

## The following initializes the development version of Bioconductor
BiocManager::install(version = "devel")

BiocManager::install("HGC")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("HGC")
HGC package manual HTML R Script
Reference Manual PDF
NEWS Text

Details

biocViews Clustering, DNASeq, GraphAndNetwork, RNASeq, SingleCell, Software
Version 1.21.0
In Bioconductor since BioC 3.13 (R-4.1) (5 years)
License GPL-3
Depends R (>= 4.1.0)
Imports Rcpp (>= 1.0.0), RcppEigen (>= 0.3.2.0), Matrix, RANN, ape, dendextend, ggplot2, mclust, patchwork, dplyr, grDevices, methods, stats
System Requirements C++11
URL
See More
Suggests BiocStyle, rmarkdown, knitr, testthat (>= 3.0.0)
Linking To Rcpp, RcppEigen
Enhances
Depends On Me
Imports Me
Suggests Me
Links To Me
Build Report Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package HGC_1.21.0.tar.gz
Windows Binary (x86_64) HGC_1.21.0.zip (64-bit only)
macOS Binary (big-sur-x86_64) HGC_1.21.0.tgz
macOS Binary (sonoma-arm64) HGC_1.21.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/HGC
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/HGC
Bioc Package Browser https://code.bioconductor.org/browse/HGC/
Package Short Url https://bioconductor.org/packages/HGC/
Package Downloads Report Download Stats